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Galantide

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名称 Galantide
CAS No. 138579-66-5
目录号 ONP10569
规格 mg/g
纯度 ≥98%
价格 更多在线询价
贮存 -20°C
分子量 2199.6
序列结构 H-GLY-TRP-THR-LEU-ASN-SER-ALA-GLY-TYR-LEU-LEU-GLY-PRO-GLN-GLN-PHE-PHE-GLY-LEU-MET-OH
库存
产品简述 The galanin-antagonist galantide, a chimeric peptide obtained from amino acids 1-13 of galanin attached to the C-terminal fragment of bradykinin, has been found to improve social memory in 'social recognition' test when i.c.v. administered at doses varying from 6-6000nmoles. Galantide causes widespread antagonism to the action of galanin and reversibly blocks the neuronal actions of galanin in a dose-dependent manner. It inhibits the release of acetylcholine, reduces the response to galanin in the hypothalamus, and blocks the effect of galanin on glucose-induced insulin secretion.