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Kahalalide F
添加购物车| 名称 | Kahalalide F |
|---|---|
| CAS No. | 149204-42-2 |
| 目录号 | ONP20176 |
| 规格 | mg/g/kg |
| 纯度 | ≥98% |
| 价格 | 更多在线询价 |
| 贮存 | -20°C |
| 分子量 | 1477.899 |
| 序列结构 | N/A |
| 库存 | |
| 产品简述 | Kahalalide F is a depsipeptide derived from the sea slug Elysia rufescens. This compound alters the function of the lysosomal membranes, a mechanism that distinguishes it from all other known antitumor agents. Other mechanisms of action are inhibition of the TGF-α expression, blockade of intracellular signaling pathways downstream of EGF and ErbB2 receptor family, and induction of non-p53-mediated apoptosis. Kahalalide F is currently in Phase II clinical trials in hepatocellular carcinoma, non-small cell lung cancer (NSCLC), and melanoma, and is also being evaluated for the treatment of severe psoriasis. |