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Pristinamycin IA
添加购物车| 名称 | Pristinamycin IA |
|---|---|
| CAS No. | 3131-03-1 |
| 目录号 | ONP12146 |
| 规格 | mg/g |
| 纯度 | ≥98% |
| 价格 | 更多在线询价 |
| 贮存 | -20°C |
| 分子量 | 866.96 |
| 序列结构 | |
| 库存 | |
| 产品简述 | Pristinamycin IA is a cyclo-peptidic macrolactone antibiotic belonging to the streptogramin family, a substrate for the P-glycoprotein. In vitro: Pristinamycin IA specifically inhibits the efflux of the P-glycoprotein substrate [3H]vinblastine, thus increasing the cellular accumulation of the drug. Pristinamycin IA also reduces by 70% the basolateral to apical secretion of [3H]vinblastine across Caco-2 cell monolayers. The cellular accumulation of [14C]pristinamycin IA is very low and is increased by P-glycoprotein inhibitors (verapamil, chlorpromazine and reserpine). |